Review: description of the developmental patterns of epithelial cells and cancers originating from them will provide many sites for therapy.

Abstract excerpt

Many types of cancers represent different forms of blocked differentiation, but the relationship with major, currently identified cancer driver mutational and epigenetic events is not well defined. Normal cellular differentiation depends upon hierarchically-organized sequences of control and synthetic events coupled with cellular proliferation. An ability to identify and possibly correct or otherwise modify...

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