Article
Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.
Oncogene - 17 Mar 2016
Marques E, Englund J I, Tervonen T A, Virkunen E, Laakso M, Myllynen M, Mäkelä A, Ahvenainen M, Lepikhova T, Monni O, Hautaniemi S, Klefström J
Abstract excerpt
Differentiated epithelial structure communicates with individual constituent epithelial cells to suppress their proliferation activity. However, the pathways linking epithelial structure to cessation of the cell proliferation machinery or to unscheduled proliferation in the context of tumorigenesis are not well defined. Here we demonstrate the strong impact of compromised epithelial integrity on normal and...
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