Article

Spatial cancer systems biology resolves heterotypic interactions and identifies disruption of spatial hierarchy as a pathological driver event

2023-03-02

Abstract excerpt

Spatially annotated single-cell datasets provide unprecedented opportunities to dissect cell-cell communication in development and disease. Heterotypic signaling includes interactions between different cell types and is well established in tissue development and spatial organization. Epithelial organization requires several different programs that are tightly regulated. Planar cell polarity (PCP) is the organizati...

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Literature Corpus work: 9c4c58e5-4d39-5bfe-941a-343be1c8f254
DOI: 10.1101/2023.03.01.530706

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