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Article

Genetic requirements for inheritance of RNAi in C. elegans.

Science (New York, N.Y.) - 31 Mar 2000

Grishok A, Tabara H, Mello C C

Abstract excerpt

In Caenorhabditis elegans, the introduction of double-stranded RNA triggers sequence-specific genetic interference (RNAi) that is transmitted to offspring. The inheritance properties associated with this phenomenon were examined. Transmission of the interference effect occurred through a dominant extragenic agent. The wild-type activities of the RNAi pathway genes rde-1 and rde-4 were required for the formation...

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Identifiers

PMID: 10741970
DOI: 10.1126/science.287.5462.2494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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