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Article

Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2011

Burton Nick O, Burkhart Kirk B, Kennedy Scott

Abstract excerpt

RNA interference (RNAi) is heritable in Caenorhabditis elegans; the progeny of C. elegans exposed to dsRNA inherit the ability to silence genes that were targeted by RNAi in the previous generation. Here we investigate the mechanism of RNAi inheritance in C. elegans. We show that exposure of animals to dsRNA results in the heritable expression of siRNAs and the heritable deposition of histone 3 lysine 9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22106253
DOI: 10.1073/pnas.1113310108
PMCID: PMC3241819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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