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Article

Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity.

The Journal of biological chemistry - 14 Jul 2017

Wang Liwei, Wagner Larry E, Alzayady Kamil J, Yule David I

Abstract excerpt

The inositol 1,4,5 trisphosphate receptor (IP3R) is an intracellular Ca2+ release channel expressed predominately on the membranes of the endoplasmic reticulum. IP3R1 can be cleaved by caspase or calpain into at least two receptor fragments. However, the functional consequences of receptor fragmentation are poorly understood. Our previous work has demonstrated that IP3R1 channels, formed following either...

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Identifiers

PMID: 28526746
DOI: 10.1074/jbc.M117.789917
PMCID: PMC5512067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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