Article
Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity.
The Journal of biological chemistry - 14 Jul 2017
Wang Liwei, Wagner Larry E, Alzayady Kamil J, Yule David I
Abstract excerpt
The inositol 1,4,5 trisphosphate receptor (IP3R) is an intracellular Ca2+ release channel expressed predominately on the membranes of the endoplasmic reticulum. IP3R1 can be cleaved by caspase or calpain into at least two receptor fragments. However, the functional consequences of receptor fragme...
Topics
- Amino Acid Substitution
- Animals
- Calcium Signaling
- Cell Line
- Chickens
- Cyclic AMP-Dependent Protein Kinases
- Gene Knockout Techniques
- Green Fluorescent Proteins
- Humans
- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Trisphosphate Receptors
- Kinetics
- Mutation
- Patch-Clamp Techniques
- Peptide Fragments
- Phosphorylation
- Protein Processing, Post-Translational
- Proteolysis