Article
Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival.
Biochimica et biophysica acta - 1 Oct 2014
Ivanova Hristina, Vervliet Tim, Missiaen Ludwig, Parys Jan B, De Smedt Humbert, Bultynck Geert
Abstract excerpt
Cell-death and -survival decisions are critically controlled by intracellular Ca(2+) homeostasis and dynamics at the level of the endoplasmic reticulum (ER). Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) play a pivotal role in these processes by mediating Ca(2+) flux from the ER into the c...
Topics
- Animals
- Calcium
- Calcium Signaling
- Cell Death
- Cell Survival
- Endoplasmic Reticulum
- Endoplasmic Reticulum Stress
- Gene Expression Regulation
- Genetic Variation
- Homeostasis
- Humans
- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Trisphosphate Receptors
- Protein Isoforms