Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis.

doi:10.1074/jbc.M403872200

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Article

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis.

The Journal of biological chemistry - 8 Oct 2004

Assefa Zerihun, Bultynck Geert, Szlufcik Karolina, Nadif Kasri Nael, Vermassen Elke, Goris Jozef, Missiaen Ludwig, Callewaert Geert, Parys Jan B, De Smedt Humbert

Abstract excerpt

Inositol 1,4,5-trisphosphate receptor-deficient (IP3RKO) B-lymphocytes were used to investigate the functional relevance of type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) and its cleavage by caspase-3 in apoptosis. We showed that inositol 1,4,5-trisphosphate receptor-deficient cells were largely resistant to apoptosis induced by both staurosporine (STS) and B-cell receptor (BCR) stimulation. Expression of...

Topics

Animals
Apoptosis
B-Lymphocytes
Calcium
Calcium Channels
Caspase 3
Caspases
Cell Death
Cell Membrane
Cerebellum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chickens

Culture Media, Serum-Free

Cytosol

DNA

Enzyme Inhibitors

Flow Cytometry

Gene Deletion

Inositol 1,4,5-Trisphosphate

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Open in PubMed

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PMID: 15284241
DOI: 10.1074/jbc.M403872200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15284241-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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