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Article

A sustained increase in the intracellular Ca²⁺ concentration induces proteolytic cleavage of EAG2 channel.

The international journal of biochemistry & cell biology - 1 Feb 2015

Shimizu Nobuhiro, Sato Natsumi, Kikuchi Teppei, Ishizaki Takuro, Kobayashi Kazuto, Kita Kaori, Takimoto Koichi

Abstract excerpt

Voltage-gated EAG2 channel is abundant in the brain and enhances cancer cell growth by controlling cell volume. The channel contains a cyclic nucleotide-binding homology (CNBH) domain and multiple calmodulin-binding motifs. Here we show that a raised intracellular Ca(2+) concentration causes prot...

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Source

Identifiers

PMID: 25542181
DOI: 10.1016/j.biocel.2014.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25542181-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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