Article
Mechanism of proteasomal degradation of inositol trisphosphate receptors in CHO-K1 cells.
The Journal of biological chemistry - 10 Feb 2006
Bhanumathy Cunnigaiper D, Nakao Steven K, Joseph Suresh K
Abstract excerpt
myo-Inositol 1,4,5-trisphosphate receptor (IP3R) degradation occurs in response to carbachol (Cch) stimulation of CHO-K1 cells. The response was mediated by endogenous muscarinic receptors and was blocked by atropine or proteasomal inhibitors. We have used these cells to identify the sites of ubi...
Topics
- Alternative Splicing
- Animals
- CHO Cells
- Calcium
- Calcium Channels
- Carbachol
- Caspase 3
- Caspases
- Cholinergic Agonists
- Cricetinae
- Cytosol
- DNA, Complementary
- Down-Regulation
- Endoplasmic Reticulum
- Enzyme Inhibitors
- Inositol 1,4,5-Trisphosphate Receptors
- Mutation
- Proteasome Endopeptidase Complex