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Article

Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation.

The Journal of biological chemistry - 12 Mar 2004

Chen Chii-Heui, Paing May M, Trejo JoAnn

Abstract excerpt

Protease-activated receptor 1 (PAR1), a G protein-coupled receptor (GPCR) for thrombin, is the prototypic member of a family of protease-activated receptors. PAR1 is irreversibly proteolytically activated; thus, the magnitude and duration of thrombin cellular responses are determined primarily by mechanisms responsible for termination of receptor signaling. Both phosphorylation and beta-arrestins contribute to...

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Identifiers

PMID: 14699102
DOI: 10.1074/jbc.M310590200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation.PMID 14699102Read ↗

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