Article
Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation.
The Journal of biological chemistry - 12 Mar 2004
Chen Chii-Heui, Paing May M, Trejo JoAnn
Abstract excerpt
Protease-activated receptor 1 (PAR1), a G protein-coupled receptor (GPCR) for thrombin, is the prototypic member of a family of protease-activated receptors. PAR1 is irreversibly proteolytically activated; thus, the magnitude and duration of thrombin cellular responses are determined primarily by mechanisms responsible for termination of receptor signaling. Both phosphorylation and beta-arrestins contribute to...
Topics
- Animals
- Arrestins
- COS Cells
- Cytoplasm
- DNA, Complementary
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Gene Expression Regulation
- Humans
- Hydrolysis
- Immunoblotting
- Microscopy, Confocal
- Microscopy, Fluorescence