Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 15 May 2017

Jia Y L, Fu Z X, Zhang B H, Jia Y J

Abstract excerpt

Down syndrome cell adhesion molecule (DSCAM) is located within the Down syndrome critical region of chromosome 21. DSCAM is a broadly expressed neurodevelopmental protein involved in synaptogenesis, neurite outgrowth, and axon guidance. We previously demonstrated DSCAM overexpression in the cortex of amyloid precursor protein (APP) transgenic mice, suggesting possible regulatory interactions between APP and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Adhesion Molecules

Share to Down Syndrome

Share to Hippocampus

Share to Learning Disabilities

Share to Memory Disorders

Share to Mice, Transgenic

Source

Open in PubMed Open full text

Identifiers

PMID: 28513774
DOI: 10.1590/1414-431X20176049
PMCID: PMC5479388

Genes

APP
DSCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice.PMID 28513774Read ↗

DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex.Semantic proximity Read ↗

Cognitive behavioral phenotyping of DSCAM heterozygosity as a model for autism spectrum disorder.Semantic proximity Read ↗

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous systemSemantic proximity Read ↗

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse modelsSemantic proximity Read ↗

A novel mouse Dscam mutation inhibits localization and shedding of DSCAM.Semantic proximity Read ↗

Cognitive behavioral phenotyping of <i>DSCAM</i> heterozygosity as a model for autism spectrum disorderSemantic proximity Read ↗

<i>Dscam</i> gene triplication causes neocortical overinhibition in Down syndromeSemantic proximity Read ↗

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndromeSemantic proximity Read ↗

Potential involvement of DSCAML1 mutations in neurodevelopmental disorders.Semantic proximity Read ↗

The role of Down syndrome cell adhesion molecule in Down syndromeSemantic proximity Read ↗

Age-Related Neurodegeneration and Memory Loss in Down SyndromeSemantic proximity Read ↗

Selectively Reduced Expression of Synaptic Plasticity-Related Genes in Amyloid Precursor Protein + Presenilin-1 Transgenic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.