Article
Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity.
The Journal of biological chemistry - 11 Jul 2003
Sakoda Hideyuki, Gotoh Yukiko, Katagiri Hideki, Kurokawa Mineo, Ono Hiraku, Onishi Yukiko, Anai Motonobu, Ogihara Takehide, Fujishiro Midori, Fukushima Yasushi, Abe Miho, Shojima Nobuhiro, Kikuchi Masatoshi, Oka Yoshitomo, Hirai Hisamaru, Asano Tomoichiro
Abstract excerpt
Serum- and glucocorticoid-regulated kinase (SGK) is a serine kinase that has a catalytic domain homologous to that of Akt, but lacks the pleckstrin homology domain present in Akt. Akt reportedly plays a key role in various cellular actions, including glucose transport, glycogen synthesis, DNA synthesis, anti-apoptotic activity, and cell proliferation. In this study, we attempted to reveal the different roles of...
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