Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver.

doi:10.1172/JCI15880

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Article

Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver.

The Journal of clinical investigation - 1 Nov 2002

Miyake Kazuaki, Ogawa Wataru, Matsumoto Michihiro, Nakamura Takehiro, Sakaue Hiroshi, Kasuga Masato

Abstract excerpt

The physiological relevance of phosphoinositide 3-kinase (PI 3-K) signaling in the liver to fuel homeostasis was investigated. Systemic infusion of an adenovirus encoding a dominant negative mutant of PI 3-K ((Delta)p85) resulted in liver-specific expression of this protein and in inhibition of the insulin-induced activation of PI 3-K in the liver within 3 days, without affecting insulin signaling in skeletal...

Topics

Adenoviridae
Adipose Tissue
Animals
Gene Transfer Techniques
Glucose
Glucose Intolerance
Hyperinsulinism
Hyperlipidemias
Insulin
Lac Operon
Lipid Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Male

Mice

Mice, Inbred BALB C

Mice, Transgenic

Muscle, Skeletal

Mutation

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Identifiers

PMID: 12438446
DOI: 10.1172/JCI15880
PMCID: PMC151813

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