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Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology

12 May 2017

Abstract excerpt

Pancreatic-type ribonucleases (ptRNases) comprise a class of highly conserved secretory endoribonucleases in vertebrates. The prototype of this enzyme family is ribonuclease 1 (RNase 1). Understanding the physiological roles of RNase 1 is becoming increasingly important, as engineered forms of the enzyme progress through clinical trials as chemotherapeutic agents for cancer. Here, we present an in-depth...

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PMID: 28495858
DOI: 10.1042/bcj20170173

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