Rapid evolution of a unique family of primate ribonuclease genes.

doi:10.1038/ng0695-219

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Article

Rapid evolution of a unique family of primate ribonuclease genes.

Nature genetics - 1 Jun 1995

Rosenberg H F, Dyer K D, Tiffany H L, Gonzalez M

Abstract excerpt

We have traced the rapid molecular evolution of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), two host defense proteins that are members of the mammalian ribonuclease gene family. The EDN/ECP gene pair arose from a recent duplication event that occurred after the divergence of New World and Old World monkeys. Since duplication, the genes encoding EDN and ECP have accumulated...

Topics

Amino Acids
Animals
Biological Evolution
Blood Proteins
Chromosome Mapping
Eosinophil Granule Proteins
Eosinophil-Derived Neurotoxin
Humans
Inflammation Mediators
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurotoxins

Primates

Rats

Ribonuclease, Pancreatic

Ribonucleases

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 7663519
DOI: 10.1038/ng0695-219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7663519-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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