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Article

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure.

Nature - 8 Sept 2005

Sambashivan Shilpa, Liu Yanshun, Sawaya Michael R, Gingery Mari, Eisenberg David

Abstract excerpt

Amyloid or amyloid-like fibrils are elongated, insoluble protein aggregates, formed in vivo in association with neurodegenerative diseases or in vitro from soluble native proteins, respectively. The underlying structure of the fibrillar or 'cross-beta' state has presented long-standing, fundamental puzzles of protein structure. These include whether fibril-forming proteins have two structurally distinct stable...

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PMID: 16148936
DOI: 10.1038/nature03916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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