Article
Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.
RNA (New York, N.Y.) - 1 Mar 2001
Dong B, Niwa M, Walter P, Silverman R H
Abstract excerpt
RNase L and Ire1p are members of a superfamily of regulated endoribonucleases that play essential roles in mediating diverse types of cellular stress responses. 2'-5' oligoadenylates, produced in response to interferon treatment and viral double-stranded RNA, are necessary to activate RNase L. In contrast, unfolded proteins in the endoplasmic reticulum activate Ire1p, a transmembrane serine/threonine kinase and...
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