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Article

RNase 1 genes from the family Sciuridae define a novel rodent ribonuclease cluster.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2000

Siegel Steven J, Percopo Caroline M, Dyer Kimberly D, Zhao Wei, Roth V Louise, Mercer John M, Rosenberg Helene F

Abstract excerpt

The RNase A ribonucleases are a complex group of functionally diverse secretory proteins with conserved enzymatic activity. We have identified novel RNase 1 genes from four species of squirrel (order Rodentia, family Sciuridae). Squirrel RNase 1 genes encode typical RNase A ribonucleases, each with eight cysteines, a conserved CKXXNTF signature motif, and a canonical His(12)-Lys(41)-His(119) catalytic triad. Two...

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Identifiers

PMID: 19771477
DOI: 10.1007/s00335-009-9215-4
PMCID: PMC2809794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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