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Structure of the <i>Thomasclavelia ramosa</i> immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases

2025-01-02

Abstract excerpt

Immunoglobulin A proteases (IgAPs) are a diverse group of enzymes secreted from bacteria that inhabit human mucosal tissues. These enzymes have convergently evolved to cleave human immunoglobulin A as a means of modulating and evading host immunity. Only two of three known IgAP families have been biochemically characterized beyond their initial discovery. Here, we show using solution-scattering, steady-state kinet...

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Identifiers and source

Literature Corpus work
b56a1826-88fc-56cd-a355-8df9a3384add
DOI
10.1101/2024.12.31.630911
Open publication

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Structure of the <i>Thomasclavelia ramosa</i> immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteasesDOI 10.1101/2024.12.31.630911
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