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Article

C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness.

Signal transduction and targeted therapy - 2 Apr 2025

Ma Jun, Yang Xiangyu, Li Yanan, Zhang Xin, Liu Kai, Peng Yong, Wang Si, Shi Rufeng, Huo Xingwei, Liu Xueting, Li Xinran, Ye Runyu, Zhang Zhipeng, Yang Changqiang, Liu Lu, Gao Dan, Jia Shanshan, Sun Lirong, Zuo Xianghao, Meng Qingtao, Chen Xiaoping

Abstract excerpt

Arterial stiffness is a critical factor in cardiovascular and cerebrovascular events, yet clinical practice lacks specific therapeutic targets and biomarkers for its assessment. Hyperlipidemia closely correlates with arterial stiffness, and we observed elevated CCAAT/enhancer-binding protein β (C/EBPβ) expression in atherosclerotic mouse arterial walls. As the arterial medial layer predominantly consists of...

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Identifiers

PMID: 40169541
DOI: 10.1038/s41392-025-02196-w
PMCID: PMC11962150

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