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The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

13 Mar 2023

Abstract excerpt

Abstract Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of endothelial Tie1 receptor tyrosine kinase is enhanced at these sites, and attenuation of its expression reduces atherosclerotic burden and decreases inflammation. However, Tie2 tyrosine kinase function in atherosclerosis is unknown. Here we provide genetic evidence...

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PMID: 37476204
DOI: 10.1038/s44161-023-00224-y

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