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Clonal hematopoiesis: elements associated with clonal expansion and diseases

13 Mar 2025

Abstract excerpt

Clonal hematopoiesis (CH), characterized by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations, has emerged as a significant age-related phenomenon with profound implications for human health. While initially recognized in the 1960s, recent technological advances have revealed its complex nature and widespread prevalence, affecting up to 84% of individuals aged ≥ 70 years. The...

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PMID: 40080235
DOI: 10.1007/s44313-025-00065-7

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