Article
Calcium dysregulation, IP3 signaling, and Alzheimer's disease.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Apr 2005
Stutzmann Grace E
Abstract excerpt
Ca(2+) ions subserve complex signaling roles in neurons, regulating functions ranging from gene transcription to modulation of membrane excitability. Ca(2+) ions enter the cytosol from extracellular sources, such as entry through voltage-gated channels, and by liberation from intracellular endoplasmic reticulum (ER) stores through inositol triphosphate (IP(3)) receptors and/or ryanodine (RyR) receptors....
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