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Article

Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma.

Oncotarget - 27 Jun 2017

Vakiani Efsevia, Shah Ronak H, Berger Michael F, Makohon-Moore Alvin P, Reiter Johannes G, Ostrovnaya Irina, Attiyeh Marc A, Cercek Andrea, Shia Jinru, Iacobuzio-Donahue Christine A, Solit David B, Weiser Martin R

Abstract excerpt

PURPOSE: Anastomotic recurrences (AR) occur in 2-10% of colorectal carcinoma cases after resection of primary tumor (PT). Currently, there are no molecular data investigating their genetic profile and multiple theories exist about their pathogenesis. The aim of our study was to compare the genomic profile of AR to that of the patients' corresponding matched PT and, when available, to a distant metastasis (DM)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28476018
DOI: 10.18632/oncotarget.17200
PMCID: PMC5522082

Genes

APC
ATM
KRAS

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