Article
Interlesional genomic heterogeneity in small bowel adenocarcinoma: evidence from matched primary and peritoneal metastatic lesions.
Clinics and research in hepatology and gastroenterology - 1 May 2026
Vanoli Alessandro, Parente Paola, De Lisi Giuseppe, Travaglino Erica, Antoci Francesca, Quaquarini Erica, Grillo Federica, Colella Tommaso, Antoniacomi Caterina, Guerini Camilla, Alberizzi Paola, Bortolotto Chandra, Lenti Marco Vincenzo, Pedrazzoli Paolo, Fassan Matteo, Paulli Marco, Di Sabatino Antonio, Corallo Salvatore
Abstract excerpt
This study analyzed the spatiotemporal heterogeneity of metastatic small bowel adenocarcinoma (SBA) with peritoneal involvement by examining genomic profiles of six SBAs and their corresponding peritoneal metastases using next-generation sequencing. Four cases had synchronous peritoneal metastases, showing complete genomic concordance with the primary tumors. In contrast, one of the two cases with metachronous...
Topics
- Aged
- Female
- Humans
- Middle Aged
- Adenocarcinoma
- Genetic Heterogeneity
- Intestinal Neoplasms
- Intestine, Small
- Mutation