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Article

Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.

The American journal of surgical pathology - 1 Aug 2015

Jesinghaus Moritz, Wolf Thomas, Pfarr Nicole, Muckenhuber Alexander, Ahadova Aysel, Warth Arne, Goeppert Benjamin, Sers Christine, Kloor Matthias, Endris Volker, Stenzinger Albrecht, Weichert Wilko

Abstract excerpt

A multistep model of disease progression and genomic landscape has been firmly established for colorectal cancer (CRC) primaries, but the genetic makeup of related metastases and the dynamics of genetic changes during metastatic progression are scarcely known. To address these issues, we used multigene high-coverage next-generation sequencing of 24 microsatellite-stable CRC primaries, matched normal tissue, and...

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Source

Identifiers

PMID: 25786087
DOI: 10.1097/PAS.0000000000000423

Genes

APC
BRAF
CTNNB1
KRAS
PTEN
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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