Article
Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis.
Gastroenterology - 1 Apr 2016
Koi Minoru, Garcia Melissa, Choi Chan, Kim Hyeong-Rok, Koike Junichi, Hemmi Hiromichi, Nagasaka Takeshi, Okugawa Yoshinaga, Toiyama Yuji, Kitajima Takahito, Imaoka Hiroki, Kusunoki Masato, Chen Yin-Hsiu, Mukherjee Bhramar, Boland C Richard, Carethers John M
Abstract excerpt
BACKGROUND & AIMS: Molecular events that lead to recurrence and/or metastasis after curative treatment of patients with colorectal cancers (CRCs) are poorly understood. Patients with stage II or III primary CRC with elevated microsatellite alterations at selected tetranucleotide repeats and low levels of microsatellite instability (E/L) are more likely to have disease recurrence after treatment. Hypoxia and/or...
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