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Stably expressed APOBEC3H forms a barrier for cross-species transmission of simian immunodeficiency virus of chimpanzee to humans

21 Dec 2017

Abstract excerpt

APOBEC3s (A3s) are potent restriction factors of human immunodeficiency virus type 1/ simian immunodeficiency viruses (HIV-1/SIV), and can repress cross-species transmissions of lentiviruses.HIV-1 originated from a zoonotic infection of SIV of chimpanzee (SIVcpz) to humans.However, the impact of human A3s on the replication of SIVcpz remains unclear.By using novel SIVcpz reporter viruses, we identified that human...

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PMID: 29267382
DOI: 10.1371/journal.ppat.1006746

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