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Article

A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis.

PLoS neglected tropical diseases - 1 May 2017

Chaichana Panjaporn, Chantratita Narisara, Brod Florian, Koosakulnirand Sirikamon, Jenjaroen Kemajittra, Chumseng Suchintana, Sumonwiriya Manutsanun, Burtnick Mary N, Brett Paul J, Teparrukkul Prapit, Limmathurotsakul Direk, Day Nicholas P J, Dunachie Susanna J, West T Eoin

Abstract excerpt

BACKGROUND: Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor with clinical outcomes and with immune responses in melioidosis....

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Identifiers

PMID: 28475641
DOI: 10.1371/journal.pntd.0005587
PMCID: PMC5435357

Genes

TLR5
TNF

Variants

Provenance

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