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Article

Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients.

The American journal of tropical medicine and hygiene - 1 May 2024

Yimthin Thatcha, Phunpang Rungnapa, Wright Shelton W, Thiansukhon Ekkachai, Chaisuksant Seksan, Chetchotisakd Ploenchan, Tanwisaid Kittisak, Chuananont Somchai, Morakot Chumpol, Sangsa Narongchai, Silakun Wirayut, Chayangsu Sunee, Buasi Noppol, Lertmemongkolchai Ganjana, Chantratita Narisara, West T Eoin

Abstract excerpt

Melioidosis, infection caused by Burkholderia pseudomallei, is characterized by robust innate immune responses. We have previously reported associations of TLR1 single nucleotide missense variant rs76600635 with mortality and of TLR5 nonsense variant rs5744168 with both bacteremia and mortality in single-center studies of patients with melioidosis in northeastern Thailand. The objective of this study was to...

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Identifiers

PMID: 38507807
DOI: 10.4269/ajtmh.23-0381
PMCID: PMC11066355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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