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Article

Impaired TLR5 functionality is associated with survival in melioidosis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

West T Eoin, Chantratita Narisara, Chierakul Wirongrong, Limmathurotsakul Direk, Wuthiekanun Vanaporn, Myers Nicolle D, Emond Mary J, Wurfel Mark M, Hawn Thomas R, Peacock Sharon J, Skerrett Shawn J

Abstract excerpt

Melioidosis is infection caused by the flagellated saprophyte Burkholderia pseudomallei. TLR5 is a pathogen recognition receptor activated by bacterial flagellin. We studied a genetic variant that encodes a defective TLR5 protein, TLR5(1174C)>T, to elucidate the role of TLR5 in melioidosis. We measured NF-κB activation induced by B. pseudomallei in human embryonic kidney-293 cells transfected with TLR5 and found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23447684
DOI: 10.4049/jimmunol.1202974
PMCID: PMC3607401

Genes

TLR5
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Impaired TLR5 functionality is associated with survival in melioidosis.PMID 23447684Read ↗

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