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Article

Functional TLR5 genetic variants affect human colorectal cancer survival.

Cancer research - 15 Dec 2013

Klimosch Sascha N, Försti Asta, Eckert Jana, Knezevic Jelena, Bevier Melanie, von Schönfels Witigo, Heits Nils, Walter Jessica, Hinz Sebastian, Lascorz Jesus, Hampe Jochen, Hartl Dominik, Frick Julia-Stefanie, Hemminki Kari, Schafmayer Clemens, Weber Alexander N R

Abstract excerpt

Toll-like receptors (TLR) are overexpressed on many types of cancer cells, including colorectal cancer cells, but little is known about the functional relevance of these immune regulatory molecules in malignant settings. Here, we report frequent single-nucleotide polymorphisms (SNP) in the flagellin receptor TLR5 and the TLR downstream effector molecules MyD88 and TIRAP that are associated with altered survival...

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Topics

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Share to Flagellin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Myeloid Differentiation Factor 88

Share to Receptors, Interleukin-1

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Share to Toll-Like Receptor 5

Source

Identifiers

PMID: 24154872
DOI: 10.1158/0008-5472.CAN-13-1746

Genes

TLR5
ACAA1
MYD88
TIRAP

Variants

rs5744174
rs5744174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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