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Article

Toll-like receptor 4 region genetic variants are associated with susceptibility to melioidosis.

Genes and immunity - 1 Jan 2012

West T E, Chierakul W, Chantratita N, Limmathurotsakul D, Wuthiekanun V, Emond M J, Hawn T R, Peacock S J, Skerrett S J

Abstract excerpt

Melioidosis is a tropical infection caused by the Gram-negative soil saprophyte Burkholderia pseudomallei. Despite broad exposure of northeastern Thais, disease develops in only a small proportion of individuals. Although diabetes is a risk factor, the mechanisms of host susceptibility to melioidosis are still poorly understood. We postulated that Toll-like receptors (TLRs) regulate host susceptibility to...

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Identifiers

PMID: 21776015
DOI: 10.1038/gene.2011.49
PMCID: PMC3483087

Genes

TLR4
TLR1
TLR6

Provenance

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