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Article

Screen of whole blood responses to flagellin identifies TLR5 variation associated with outcome in melioidosis.

Genes and immunity - 1 Mar 2014

Chantratita N, Tandhavanant S, Myers N D, Chierakul W, Robertson J D, Mahavanakul W, Singhasivanon P, Emond M J, Peacock S J, West T E

Abstract excerpt

Melioidosis is a severe infection caused by the flagellated bacterium Burkholderia pseudomallei. The nonsense polymorphism TLR51174C>T is associated with improved outcome in Thais with melioidosis. We hypothesized that other TLR5 variants may modulate the host response and determine outcome in melioidosis. We genotyped 12 TLR5 variants selected de novo from the HapMap database and examined the association of each...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24285178
DOI: 10.1038/gene.2013.60
PMCID: PMC3948086

Genes

TLR5

Provenance

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Screen of whole blood responses to flagellin identifies TLR5 variation associated with outcome in melioidosis.PMID 24285178Read ↗

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