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Article

Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam.

The Journal of infectious diseases - 1 Apr 2005

Dunstan Sarah J, Hawn Thomas R, Hue Nguyen Thi, Parry Christopher P, Ho Vo An, Vinh Ha, Diep To Song, House Deborah, Wain John, Aderem Alan, Hien Tran Tinh, Farrar Jeremy J

Abstract excerpt

Toll-like receptor 5 (TLR5) mediates innate immune responses to bacterial pathogens by binding to flagellin. A polymorphism in the TLR5 gene introduces a premature stop codon (TLR5(392STOP)) that is associated with susceptibility to legionnaires disease. Here we investigated whether TLR5(392STOP) was associated with typhoid fever. The frequency of TLR5(392STOP) was not significantly different in 565 patients with...

Read the complete abstract on PubMed

Topics

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Share to Flagellin
Share to Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Cell Surface

Share to Salmonella enterica

Share to Toll-Like Receptor 5

Share to Toll-Like Receptors

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Source

Identifiers

PMID: 15747241
DOI: 10.1086/428593

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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