Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.

doi:10.1371/journal.ppat.1006359

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Article

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.

PLoS pathogens - 1 May 2017

Fennessey Christine M, Pinkevych Mykola, Immonen Taina T, Reynaldi Arnold, Venturi Vanessa, Nadella Priyanka, Reid Carolyn, Newman Laura, Lipkey Leslie, Oswald Kelli, Bosche William J, Trivett Matthew T, Ohlen Claes, Ott David E, Estes Jacob D, Del Prete Gregory Q, Lifson Jeffrey D, Davenport Miles P, Keele Brandon F

Abstract excerpt

HIV and SIV infection dynamics are commonly investigated by measuring plasma viral loads. However, this total viral load value represents the sum of many individual infection events, which are difficult to independently track using conventional sequencing approaches. To overcome this challenge, we generated a genetically tagged virus stock (SIVmac239M) with a 34-base genetic barcode inserted between the vpx and...

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PMID: 28472156
DOI: 10.1371/journal.ppat.1006359
PMCID: PMC5433785

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