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Article

CD8ɑ+ cells suppress SIV replication without the development of mutations within MHC class-I-restricted epitopes during post-treatment control.

Journal of virology - 21 Jul 2026

Moriarty Ryan V, Harwood Olivia E, Johnson Ethan P, Gardner William, Valencia Corina C, Conchas Andrew, Immonen Taina T, Reynolds Matthew R, Keele Brandon F, O'Connor Shelby L

Abstract excerpt

Post-treatment control (PTC) is a rare phenomenon in which people living with HIV (PLWH) maintain viral control following antiretroviral treatment (ART) interruption. Characterizing virus populations present in PTCs may help elucidate mechanisms of immunologic control, but this is challenging without detectable plasma viremia. To model PTC, eight Mauritian cynomolgus macaques (MCMs) were infected with barcoded...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42295005
DOI: 10.1128/jvi.00041-26
PMCID: PMC13386877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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