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CD8ɑ+ cells suppress SIV replication without the development of mutations within MHC class-I-restricted epitopes during post-treatment control.

Journal of virology - 21 Jul 2026

Moriarty Ryan V, Harwood Olivia E, Johnson Ethan P, Gardner William, Valencia Corina C, Conchas Andrew, Immonen Taina T, Reynolds Matthew R, Keele Brandon F, O'Connor Shelby L

Abstract excerpt

Post-treatment control (PTC) is a rare phenomenon in which people living with HIV (PLWH) maintain viral control following antiretroviral treatment (ART) interruption. Characterizing virus populations present in PTCs may help elucidate mechanisms of immunologic control, but this is challenging without detectable plasma viremia. To model PTC, eight Mauritian cynomolgus macaques (MCMs) were infected with barcoded...

Topics

Animals
Simian Immunodeficiency Virus
Simian Acquired Immunodeficiency Syndrome
CD8-Positive T-Lymphocytes
Virus Replication
Macaca fascicularis
Viral Load
Mutation
CD8 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viremia

Histocompatibility Antigens Class I

Anti-Retroviral Agents

Epitopes, T-Lymphocyte

Source

Open in PubMed Open full text

Identifiers

PMID: 42295005
DOI: 10.1128/jvi.00041-26
PMCID: PMC13386877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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