Article
Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events.
Journal of virology - 1 Jul 2014
Del Prete Gregory Q, Park Haesun, Fennessey Christine M, Reid Carolyn, Lipkey Leslie, Newman Laura, Oswald Kelli, Kahl Christoph, Piatak Michael, Quiñones Octavio A, Alvord W Gregory, Smedley Jeremy, Estes Jacob D, Lifson Jeffrey D, Picker Louis J, Keele Brandon F
Abstract excerpt
Following mucosal human immunodeficiency virus type 1 transmission, systemic infection is established by one or only a few viral variants. Modeling single-variant, mucosal transmission in nonhuman primates using limiting-dose inoculations with a diverse simian immunodeficiency virus isolate stock may increase variability between animals since individual variants within the stock may have substantial functional...
Read the complete abstract on PubMedTopics
- Animals
- Disease Models, Animal
- Genetic Variation
- Genotype
- Longitudinal Studies
