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Article

Residual viremia in an RT-SHIV rhesus macaque HAART model marked by the presence of a predominant plasma clone and a lack of viral evolution.

PloS one - 1 Jan 2014

Kauffman Robert C, Villalobos Andradi, Bowen Joanne H, Adamson Lourdes, Schinazi Raymond F

Abstract excerpt

Highly active antiretroviral therapy (HAART) significantly reduces HIV-1 replication and prevents progression to AIDS. However, residual low-level viremia (LLV) persists and long-lived viral reservoirs are maintained in anatomical sites. These reservoirs permit a recrudescence of viremia upon cessation of therapy and thus HAART must be maintained indefinitely. HIV-1 reservoirs include latently infected resting...

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Identifiers

PMID: 24505452
DOI: 10.1371/journal.pone.0088258
PMCID: PMC3914964

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Source receipt: pubmed, retrieved 7 Sept 2026.

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