Article
Generation of neutralizing antibodies and divergence of SIVmac239 in cynomolgus macaques following short-term early antiretroviral therapy.
PLoS pathogens - 2 Sept 2010
Ozkaya Sahin Gülşen, Bowles Emma J, Parker Joe, Uchtenhagen Hannes, Sheik-Khalil Enas, Taylor Stephen, Pybus Oliver G, Mäkitalo Barbro, Walther-Jallow Lilian, Spångberg Mats, Thorstensson Rigmor, Achour Adnane, Fenyö Eva Maria, Stewart-Jones Guillaume B E, Spetz Anna-Lena
Abstract excerpt
Neutralizing antibodies (NAb) able to react to heterologous viruses are generated during natural HIV-1 infection in some individuals. Further knowledge is required in order to understand the factors contributing to induction of cross-reactive NAb responses. Here a well-established model of experimental pathogenic infection in cynomolgus macaques, which reproduces long-lasting HIV-1 infection, was used to study...
Topics
- Amino Acid Substitution
- Animals
- Anti-Retroviral Agents
- Antibodies, Neutralizing
- Biological Evolution
- Genetic Variation
- Immunoglobulin G
- Macaca fascicularis
- Male