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Article

Genetic variation and RNA structure regulate microRNA biogenesis.

Nature communications - 3 May 2017

Fernandez Noemi, Cordiner Ross A, Young Robert S, Hug Nele, Macias Sara, Cáceres Javier F

Abstract excerpt

MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of sequence and secondary RNA structure in this process has not been extensively studied. A single G to A substitution present in the terminal loop of pri-mir-30c-1 in breast and gastric cancer patients had been previously described to result in increased levels of mature miRNA. Here, we report that this genetic variant...

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Identifiers

PMID: 28466845
DOI: 10.1038/ncomms15114
PMCID: PMC5418625

Genes

SRSF3

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