Article

Changes in miRNA secondary structure can predict mutations associated with cancer and other diseases

2024-06-22

Abstract excerpt

MicroRNAs (miRNAs) are ubiquitous short RNAs regulating gene expression in many organisms, including humans. How the secondary structure (SS) of a mature miRNA affects its regulatory function remains an open question. Here we investigate this question through computational SS predictions of miRNA point mutants. We explore the mutational neighborhoods of miRNAs with association to human diseases, including cancer....

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Literature Corpus work: d8a6977f-4f05-5926-b7be-5b8c20219bb0
DOI: 10.1101/2024.06.19.599688

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