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Article

SNPs in human miRNA genes affect biogenesis and function.

RNA (New York, N.Y.) - 1 Sept 2009

Sun Guihua, Yan Jin, Noltner Katie, Feng Jinong, Li Haitang, Sarkis Daniel A, Sommer Steve S, Rossi John J

Abstract excerpt

MicroRNAs (miRNAs) are 21-25-nucleotide-long, noncoding RNAs that are involved in translational regulation. Most miRNAs derive from a two-step sequential processing: the generation of pre-miRNA from pri-miRNA by the Drosha/DGCR8 complex in the nucleus, and the generation of mature miRNAs from pre-miRNAs by the Dicer/TRBP complex in the cytoplasm. Sequence variation around the processing sites, and sequence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19617315
DOI: 10.1261/rna.1560209
PMCID: PMC2743066

Genes

DGCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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