Genetic variation and RNA structure regulate microRNA biogenesis

Abstract excerpt

MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of sequence and secondary RNA structure in this process has not been extensively studied. A single G to A substitution present in the terminal loop of pri-mir-30c-1 in breast cancer patients had been previously described to result in increased levels of mature miRNA. Here, we report that this genetic variant directly affects...

Topics

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• In Vitro Techniques
• MCF-7 Cells
• Nucleic Acid Conformation
• Ribonuclease III
• RNA
• RNA Processing, Post-Transcriptional
• Serine-Arginine Splicing Factors
• Stomach Neoplasms

Identifiers and source

Literature Corpus work

684d4864-9353-536c-83ad-f1de46352bdb

DOI

10.1101/093179