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Article

Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma.

PloS one - 1 Jan 2017

Acevedo Nathalie, Ezer Sini, Kebede Merid Simon, Gaertner Vincent D, Söderhäll Cilla, D'Amato Mauro, Kabesch Michael, Melén Erik, Kere Juha, Pulkkinen Ville

Abstract excerpt

Single nucleotide polymorphisms (SNPs) close to the gain-of-function substitution, Asn(107)Ile (rs324981, A>T), in Neuropeptide S Receptor 1 (NPSR1) have been associated with asthma. Furthermore, a functional SNP (rs4751440, G>C) in Neuropeptide S (NPS) encodes a Val(6)Leu substitution on the mature peptide that results in reduced bioactivity. We sought to examine the effects of different combinations of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asthma
Share to Child
Share to Epistasis, Genetic
Share to Genetic Predisposition to Disease
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Share to Polymorphism, Single Nucleotide
Share to Real-Time Polymerase Chain Reaction
Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 28463995
DOI: 10.1371/journal.pone.0176568
PMCID: PMC5413018

Genes

NPS
NPSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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