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Article

The asthma candidate gene NPSR1 mediates isoform specific downstream signalling.

BMC pulmonary medicine - 27 Jun 2011

Pietras Christina Orsmark, Vendelin Johanna, Anedda Francesca, Bruce Sara, Adner Mikael, Sundman Lilli, Pulkkinen Ville, Alenius Harri, D'Amato Mauro, Söderhäll Cilla, Kere Juha

Abstract excerpt

BACKGROUND: Neuropeptide S Receptor 1 (NPSR1, GPRA, GPR154) was first identified as an asthma candidate gene through positional cloning and has since been replicated as an asthma and allergy susceptibility gene in several independent association studies. In humans, NPSR1 encodes two G protein-coupled receptor variants, NPSR1-A and NPSR1-B, with unique intracellular C-termini. Both isoforms show distinct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21707994
DOI: 10.1186/1471-2466-11-39
PMCID: PMC3142248

Genes

NPSR1
NPS

Provenance

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