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Article

Multiple polymorphisms affect expression and function of the neuropeptide S receptor (NPSR1).

PloS one - 1 Jan 2011

Anedda Francesca, Zucchelli Marco, Schepis Danika, Hellquist Anna, Corrado Lucia, D'Alfonso Sandra, Achour Adnane, McInerney Gerald, Bertorello Alejandro, Lördal Mikael, Befrits Ragnar, Björk Jan, Bresso Francesca, Törkvist Leif, Halfvarson Jonas, Kere Juha, D'Amato Mauro

Abstract excerpt

BACKGROUND: neuropeptide S (NPS) and its receptor NPSR1 act along the hypothalamic-pituitary-adrenal axis to modulate anxiety, fear responses, nociception and inflammation. The importance of the NPS-NPSR1 signaling pathway is highlighted by the observation that, in humans, NPSR1 polymorphism associates with asthma, inflammatory bowel disease, rheumatoid arthritis, panic disorders, and intermediate phenotypes of...

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Source

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Identifiers

PMID: 22216302
DOI: 10.1371/journal.pone.0029523
PMCID: PMC3244468

Genes

NPSR1
NPS

Provenance

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