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Article

Pharmacological characterization of human and murine neuropeptide s receptor variants.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2005

Reinscheid Rainer K, Xu Yan-Ling, Okamura Naoe, Zeng Joanne, Chung Shinjae, Pai Rama, Wang Zhiwei, Civelli Olivier

Abstract excerpt

We have recently shown that Neuropeptide S (NPS) can promote arousal and induce anxiolytic-like effects after central administration in rodents. Another study reported a number of natural polymorphisms in the human NPS receptor gene. Some of these polymorphisms were associated with increased risk of asthma and possibly other forms of atopic diseases, but the physiological consequences of the mutations remain...

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Source

Identifiers

PMID: 16144971
DOI: 10.1124/jpet.105.093427

Genes

NPS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Pharmacological characterization of human and murine neuropeptide s receptor variants.PMID 16144971Read ↗

Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I.Semantic proximity Read ↗

Neuropeptide S Receptor 1 variant (I107N) regulates behavioral characteristics and NPS effect in mice in a sex-dependent manner.Semantic proximity Read ↗

Mutagenesis studies of neuropeptide S identify a suitable peptide tracer for neuropeptide S receptor binding studies and peptides selectively activating the I(107) variant of human neuropeptide S receptor.Semantic proximity Read ↗

Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma.Semantic proximity Read ↗

Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder.Semantic proximity Read ↗

A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivity.Semantic proximity Read ↗

The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response.Semantic proximity Read ↗

The Physio-Pharmacological Role of the NPS/NPSR System in Psychiatric Disorders: A Translational Overview.Semantic proximity Read ↗

Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation.Semantic proximity Read ↗

Multiple polymorphisms affect expression and function of the neuropeptide S receptor (NPSR1).Semantic proximity Read ↗

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.Semantic proximity Read ↗

Neuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disorders.Semantic proximity Read ↗

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