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Article

Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseases.

Human molecular genetics - 1 Jun 2008

Orsmark-Pietras Christina, Melén Erik, Vendelin Johanna, Bruce Sara, Laitinen Annika, Laitinen Lauri A, Lauener Roger, Riedler Josef, von Mutius Erika, Doekes Gert, Wickman Magnus, van Hage Marianne, Pershagen Göran, Scheynius Annika, Nyberg Fredrik, Kere Juha

Abstract excerpt

Neuropeptide S receptor 1 (NPSR1, GPRA 154, GPRA) has been verified as a susceptibility gene for asthma and related phenotypes. The ligand for NPSR1, Neuropeptide S (NPS), activates signalling through NPSR1 and microarray analysis has identified Tenascin C (TNC) as a target gene of NPS-NPSR1 signalling. TNC has previously been implicated as a risk gene for asthma. We aimed therefore to study the genetic...

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Topics

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Share to Asthma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Hypersensitivity

Share to Neuropeptides

Share to Receptors, G-Protein-Coupled

Share to Rhinitis

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Source

Identifiers

PMID: 18305139
DOI: 10.1093/hmg/ddn058

Genes

TNC
NPSR1
NPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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